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Analysis Demonstrates Gastric Banding is a Safe and Cost-Effective Weight-Loss Surgery Procedure

A new study published in the peer-reviewed journal Surgery for Obesity and Related Diseases,the Official Journal of the American Society for Metabolic and Bariatric Surgery (ASMBS) and the Brazilian Society for Bariatric Surgery, found that the cost of a gastric banding weight-loss surgery procedure, such as Allergan's Lap-Band® Adjustable Gastric Banding System, was offset by reductions in…See More
Blog post by Peter Hofland, PhD Jun 22, 2011
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Superior BP Reductions in Diabetic Patients Treated with Telmisartan/Amlodipine

Results show that in hypertensive patients with diabetes who are at added risk of cardiovascular (CV) events, TWYNSTA® (Boehringer Ingelheim GmbH), the single pill combination of the angiotensin II receptor blocker (ARB) telmisartan and the calcium channel blocker (CCB) amlodipine, compared to amlodipine alone delivers superior blood pressure (BP) reductions needed to get these added risk patients to BP goal. [1]The new data show that the…See More
Blog post by Peter Hofland, PhD Jun 18, 2011
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Kristie Reece is now a member of The Diabetes Challenge Jun 10, 2011
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Comprehensive Data Review Shows Added Sugar Intake Directly Correlated Weight Gain

A Crucial topic of today's Science and Nutrition Research is related to the intake of carbohydrates, sugars and starches.Trends in weight gain have paralleled dietary trends in the increased intake of added sugars, according to a review of 27 years of Minnesota Heart Survey. The data has been presented at an American Heart Association (AHA) event.The AHA's Nutrition, Physical Activity and Metabolism/Cardiovascular…See More
Blog post by Peter Hofland, PhD May 22, 2011
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David Stevens is now a member of The Diabetes Challenge May 9, 2011
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High Dose Omega 3 May Help Lower Triglycerides

In a placebo-controlled, double-blind, randomized trial, 26 adults with moderately elevated triglycerides (between 150-500 mg/dL) were given either 0.85 or 3.4 grams per day of the omega 3 fatty acids EPA and DHA for eight weeks.The higher dosage lowered triglycerides by 27% compared to the placebo (173 ± 17.5 compared with 237 ± 17.5 mg/dL; P = 0.002). No effect on triglycerides was seen at the lower dose. Neither dosage of omega 3 fatty acids had any effect on markers of inflammation or…See More
Blog post by Peter Hofland, PhD Apr 28, 2011
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Blog posts by Peter Hofland, PhD Apr 16, 2011
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Blog posts by Peter Hofland, PhD Mar 12, 2011

Events

Diabetes and Cancer - A Consensus Report

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments. A consensus statement of experts assembled jointly by the American Diabetes Association and the American Cancer Society reviews the state of science concerning:
1 - the association between diabetes and cancer incidence or prognosis,
2 - risk factors common to both diabetes and cancer,
3 - possible biologic links between diabetes and cancer risk, and
4 - whether diabetes treatments influence risk of cancer or cancer prognosis.
In addition, key unanswered questions for future research are posed. Diabetes and Cancer Consensus Report
 


Blog Posts

Peter Hofland, PhD

Analysis Demonstrates Gastric Banding is a Safe and Cost-Effective Weight-Loss Surgery Procedure

A new study published in the peer-reviewed journal Surgery for Obesity and Related Diseases,the Official Journal of the American Society for Metabolic and Bariatric Surgery (ASMBS) and the Brazilian Society for Bariatric Surgery, found that the cost of a gastric banding weight-loss surgery procedure, such as Allergan's Lap-Band® Adjustable Gastric Banding System, was offset by… Continue

Posted by Peter Hofland, PhD on June 22, 2011 at 8:30am

Peter Hofland, PhD

Superior BP Reductions in Diabetic Patients Treated with Telmisartan/Amlodipine

Results show that in hypertensive patients with diabetes who are at added risk of cardiovascular (CV) events, TWYNSTA® (Boehringer Ingelheim GmbH), the single pill combination of the angiotensin II receptor blocker (ARB) telmisartan and the calcium channel blocker (CCB) amlodipine, compared to amlodipine alone delivers superior blood pressure (BP) reductions needed to get these added risk patients to BP goal.… Continue

Posted by Peter Hofland, PhD on June 17, 2011 at 6:00am

Peter Hofland, PhD

Comprehensive Data Review Shows Added Sugar Intake Directly Correlated Weight Gain

A Crucial topic of today's Science and Nutrition Research is related to the intake of carbohydrates, sugars and starches.



Trends in weight gain have paralleled dietary trends in the increased intake of added sugars, according to a review of 27 years of Minnesota Heart Survey. The data has been presented at an American Heart Association (AHA) event.



The AHA's Nutrition,… Continue

Posted by Peter Hofland, PhD on May 19, 2011 at 9:30am

Peter Hofland, PhD

First DPP-4 Inhibitor Approved for the Treatment of T2DM

The U.S. Food and Drug Administration (FDA) has approved linagliptin tablets, a prescription medication used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.[1] The FDA has approved linagliptin as a monotherapy or in combination with other commonly prescribed medications for T2DM (type 2 diabetes) — such as metformin, sulphonylurea and pioglitazone — to reduce haemoglobin A1c (HbA1c or A1c) levels by a mean of up to -0.7%(compared to placebo).[2]… Continue

Posted by Peter Hofland, PhD on May 3, 2011 at 12:30am

Peter Hofland, PhD

High Dose Omega 3 May Help Lower Triglycerides

In a placebo-controlled, double-blind, randomized trial, 26 adults with moderately elevated triglycerides (between 150-500 mg/dL) were given either 0.85 or 3.4 grams per day of the omega 3 fatty acids EPA and DHA for eight weeks.



The higher dosage lowered triglycerides by 27% compared to the placebo (173 ± 17.5 compared with 237 ± 17.5 mg/dL; P = 0.002).



No effect on triglycerides was seen at the lower dose. Neither dosage of omega 3 fatty acids had… Continue

Posted by Peter Hofland, PhD on April 28, 2011 at 1:30pm

Peter Hofland, PhD

Study Shows that Diet Plus Exercise is Better for Weight Loss Than Either One Alone

Everyone knows that eating a low-fat, low-calorie diet and getting regular exercise helps shed pounds, but a new study led by researchers at Fred Hutchinson Cancer Research Center has found that when it comes to losing weight and body fat, diet and exercise are most effective when done together as compared to either strategy alone.



The results of this randomized trial, led by Anne McTiernan, M.D., Ph.D.,… Continue

Posted by Peter Hofland, PhD on April 15, 2011 at 6:30am

Peter Hofland, PhD

CoQ10 may be Beneficial in Cardiovascular Health; Cholesterol Control

Scientists from the Christian-Albrechts-Universityof Kiel and the University of Witten/Herdecke report that daily supplements of Co-Enzyme Q10 may impact various gene networks associated with inflammation and cell differentiation.



Using Kaneka's ubiquinol… Continue

Posted by Peter Hofland, PhD on April 15, 2011 at 6:30am

Peter Hofland, PhD

Meta-Analysis: Greater Control at Baseline A1C Levels with Liraglutide Compared to Other Therapies

Data presented today at the 20th Annual Meeting and Clinical Congress of the American Association of Clinical Endocrinologists (AACE) showed that regardless of baseline A1C, once-daily Victoza® (liraglutide [rDNA origin] injection, Novo Nordisk) 1.8 mg consistently helped more patients achieve blood sugar control than some other commonly used T2DM (type 2 diabetes) therapies. Victoza® is the first and only human… Continue

Posted by Peter Hofland, PhD on April 14, 2011 at 10:00am

Peter Hofland, PhD

Phase III Defend-1 Study of Otelixizumab in Type 1 Diabetes Does Not Meet Primary Endpoint

Results presented today show that the Phase III DEFEND-1 study of otelixizumab (Tolerx, Inc. and GlaxoSmithKline), an investigational humanized anti-CD3 monoclonal antibody, did not meet the primary efficacy endpoint of change in C-peptide at month 12 in patients with new-onset autoimmune T1DM (Type 1 Diabetes). The drug candidate is a is a targeted T cell immunotherapy designed to targets CD3, a T lymphocyte receptor involved in… Continue

Posted by Peter Hofland, PhD on March 11, 2011 at 6:30am

Peter Hofland, PhD

Investigational GLP-1 Treatment Improved Glucose Control with One Dose Per Month in Phase II Study

A phase II study evaluating the effects of a once-monthly injectable suspension formulation of exenatide on glycemic control in patients with T2DM (type 2 diabetes) shows positive results.



Diabetes affects nearly 26 million people in the U.S. and an estimated 285 million adults worldwide. [1,2] Approximately 90-95% of those affected have type 2 diabetes. Diabetes costs approximately $174 billion per year in direct and indirect medical… Continue

Posted by Peter Hofland, PhD on March 10, 2011 at 5:30am

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Diabetes Technology & Therapeutics

Patient Perceptions of Using the OmniPod System Compared with Conventional Insulin Pumps in Young Adults with Type 1 Diabetes

Does the Timing of Insulin Pump Therapy Initiation After Type 1 Diabetes Onset Have an Impact on Glycemic Control?

Stress-Induced Hyperglycemia in Healthy Bungee Jumpers Without Diabetes Due to Decreased Pancreatic β-Cell Function and Increased Insulin Resistance

Nocturnal Hypoglycemia Identified by a Continuous Glucose Monitoring System in Patients with Primary Adrenal Insufficiency (Addison's Disease)

Development of Optimal Kids Insulin Dosing System Formulas for Young Children with Type 1 Diabetes Mellitus

Continuous Glucose Monitoring in Patients Undergoing Cardiac Surgery

Study of Plasmid-Mediated Extended-Spectrum β-Lactamase-Producing Strains of Enterobacteriaceae, Isolated from Diabetic Foot Infections in a North Indian Tertiary-Care Hospital

Personalizing Treatment in Type 2 Diabetes: A Self-Monitoring of Blood Glucose Inclusive Innovative Approach

Recalculate Total Daily Dose and Confirm Exactly How Much Insulin Your Patient Is Taking Prior to Changing Mode of Insulin Delivery

Fulminant Type 1 Diabetes Mellitus: A Study of Nine Cases

Golden Rule Insurance Quotes

Clinical Diabetes Journal

Case Study: New-Onset Diabetes: How to Tell the Difference Between Type 1 and Type 2 Diabetes

In the Beginning ...

Choosing GLP-1 Receptor Agonists or DPP-4 Inhibitors: Weighing the Clinical Trial Evidence

The Crucial Role of Health Care Professionals in Advocating for Students With Diabetes

Telephone Coaching to Improve Diabetes Self-Management for Rural Residents

Case Study: Seizures and Hypoglycemia

An Innovative Approach for Predicting Severe Hypoglycemia

Strategies to Limit the Effect of Hypoglycemia on Diabetes Control: Identifying and Reducing the Risks

Angiotensin Receptor Blocker to Prevent Microalbuminuria?

Hypoglycemia? Low Blood Glucose? Low Blood Sugar?

Pediatric Diabetes (The official publication of ISPAD)

Use of continuous glucose monitoring in children and adolescents

Childhood onset diabetes posttransplant in a girl with TCF2 mutation

Xanthomata and diabetes in an adolescent with familial dysbetalipoproteinemia 9 yr after valproate-induced pancreatitis

Growth differences between North American and European children at risk for type 1 diabetes

A matter of fat: insulin resistance and oxidative stress

Incidence and modes of presentation of childhood type 1 diabetes mellitus in Malta between 2006 and 2010

Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War

Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients

FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls

stacyadams.com (Weyco Group, Inc.)

Diabetes Spectrum Journal

Predictors of Diabetic Retinopathy in a Community Health Center Population

Oral Health and Diabetes: Interprofessional Coordination of Patient-Centered Care: Preface

The Oral-Systemic Link: An Opportunity for Collaboration

Guest Editors

Motivational Interviewing Part 2: An Overview of Skills and Challenging Clinical Encounters

Diabetes and Periodontal Disease: An Update for Health Care Providers

Glycemic Control in Pharmacist-Managed Insulin Titration Versus Standard Care in an Indigent Population

Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

Reducing Disparities in Diabetes: The Alliance Model for Health Care Improvements

Health Information Exchange and Care Coordination of Diabetic Patients Between Medicine and Dentistry

Diabetic Medicine (ADA)

Response to Alleyn et al. Comparison of longitudinal point-of-care and high-performance liquid chromatography HbA1c measurements in a multi-centre trial

Effect of screening for Type 2 diabetes on population-level self-rated health outcomes and measures of cardiovascular risk: 13-year follow-up of the Ely cohort

Ethnicity modifies the relation between fasting plasma glucose and HbA1c in Indians, Malays and Chinese

Reply to Camargo et al.

Asymmetrical attenuation of vibration sensation in unilateral diabetic Charcot foot neuroarthropathy

Pancreatic exocrine function in patients with diabetes

HbA1c and glucose intolerance in obese children and adolescents

In children using intensive insulin therapy, a 20-g variation in carbohydrate amount significantly impacts on postprandial glycaemia

CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients

Comparison of renal resistive index among patients with Type 2 diabetes with different levels of creatinine clearance and urinary albumin excretion

Cardiovascular Diabetology - Latest Articles

Lp(a) cholesterol is associated with HDL-cholesterol in overweight and obese African American children and is not an independent risk factor for CVD

Acute and chronic animal models for the evaluation of anti-diabetic agents

Increase of ATP-sensitive potassium (KATP) channels in the heart of type-1 diabetic rats

RhoA/ROCK-Dependent Moesin Phosphorylation Regulates AGE-induced Endothelial Cellular Response

Platelet hyperaggregability in high-fat fed rats: A role for intraplatelet reactive-oxygen species production

Saxagliptin for the Treatment of Type 2 Diabetes Mellitus: Assessing Cardiovascular Data

Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts

Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome

Cardiovascular safety with linagliptin in patients with type 2 diabetes mellitus: A pre-specified, prospective, and adjudicated meta-analysis of a Phase 3 programme

Ramipril-based versus diuretic-based antihypertensive primary treatment in patients with pre-diabetes (ADaPT) study

Medscape Diabetes & Endocrinology Headlines

New Predictors May Determine Metabolic Risk in Kids on Atypicals

Diabetes Journal (ADA)

Potential Role of Tumor Necrosis Factor-{alpha} in Downregulating Sex Hormone-Binding Globulin

Glucocorticoid Signaling in the Arcuate Nucleus Modulates Hepatic Insulin Sensitivity

Damaging Loss of Self-Control by Stressed {beta}-Cells

L-Leucine Alters Pancreatic {beta}-Cell Differentiation and Function via the mTor Signaling Pathway

Prediabetes: Evaluation of {beta}-Cell Function

CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action

Mapping Autophagy on to Your Metabolic Radar

Postnatal Growth and DNA Methylation Are Associated With Differential Gene Expression of the TACSTD2 Gene and Childhood Fat Mass

The L-{alpha}-Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity

Role of TRIB3 in Diabetic and Overnutrition-Induced Atherosclerosis

Mothers Work, Inc.figleaves.com

Diabetes Care Journal (ADA)

Response to Comment on: Lassenius et al. Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation. Diabetes Care 2011;34:1809-1815

Response to Comment on: Ramos-Zavala et al. Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naive Patients With Type 2 Diabetes: A Randomized Clinical Trial. Diabetes Care 2011;34:1591-1594

Is the Frequency of Ketoacidosis at Onset of Type 1 Diabetes a Child Health Indicator That is Related to Income Inequality?

Response to Comment on: Leeds et al. High Prevalence of Microvascular Complications in Adults With Type 1 Diabetes and Newly Diagnosed Celiac Disease. Diabetes Care 2011;34:2158-2163

Insulin Edema in a Patient With Cystic Fibrosis-Related Diabetes

Response to Comment on: Morden et al. Further Exploration of the Relationship Between Insulin Glargine and Incident Cancer: A Retrospective Cohort Study of Older Medicare Patients. Diabetes Care 2011;34:1965-1971

RS3PE in Association With Dipeptidyl Peptidase-4 Inhibitor: Report of Two Cases

Comment on: Leeds et al. High Prevalence of Microvascular Complications in Adults With Type 1 Diabetes and Newly Diagnosed Celiac Disease. Diabetes Care 2011;34:2158-2163

Possible Influence of Ileal Neobladder on Assessment of Urinary C-peptide

Association of Type B Insulin Resistance and Type 1 Diabetes Resulting in Ketoacidosis

Clinical Diabetes Journal (ADA)

Case Study: New-Onset Diabetes: How to Tell the Difference Between Type 1 and Type 2 Diabetes

In the Beginning ...

Choosing GLP-1 Receptor Agonists or DPP-4 Inhibitors: Weighing the Clinical Trial Evidence

The Crucial Role of Health Care Professionals in Advocating for Students With Diabetes

Telephone Coaching to Improve Diabetes Self-Management for Rural Residents

Case Study: Seizures and Hypoglycemia

An Innovative Approach for Predicting Severe Hypoglycemia

Strategies to Limit the Effect of Hypoglycemia on Diabetes Control: Identifying and Reducing the Risks

Angiotensin Receptor Blocker to Prevent Microalbuminuria?

Hypoglycemia? Low Blood Glucose? Low Blood Sugar?

Diabetes & Metabolism

Dental implants and diabetes: Conditions for success

Inflammation and type 2 diabetes

Chronic kidney disease in type 2 diabetes patients in Fran Prevalence, influence of glycaemic control and implications for the pharmacological management of diabetes

Improvement of psoriasis during exenatide treatment in a patient with diabetes

Consensus statement on the care of the hyperglycaemic/diabetic patient during and in the immediate follow-up of acute coronary syndrome

Towards an artificial pancreas at home

Telemedicine: What more is needed for its integration in everyday life?

Is continuous glucose monitoring (CGM) for everyone?: To whom should CGM be prescribed and how? 

Improving diabetes management with electronic health records and patients’ health records

Technologies applied to diabetes

Journal of Diabetes and its Complications

Human bone marrow adiposity is linked with serum lipid levels not T1-diabetes

Effects of bile-acid-binding resin (colestimide) on blood glucose and visceral fat in Japanese patients with type 2 diabetes mellitus and hypercholesterolemia: an open-label, randomized, case–control, crossover study

Therapeutical potential of autologous peripheral blood mononuclear cell transplantation in patients with type 2 diabetic critical limb ischemia

Trends of insulin use among US adults with type 2 diabetes: the Behavioral Risk Factor Surveillance System, 1995–2007

Self-efficacy, self-management, and glycemic control in adults with type 2 diabetes mellitus

The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients

Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy

Clinical, biochemical, and immunological characteristics of newly diagnosed nonobese diabetic patients aged 18–45 years in China

Contents

Effects of a synthetic retinoid on skin structure, matrix metalloproteinases, and procollagen in healthy and high-risk subjects with diabetes

Diabetes Research and Clinical Practice

Contents

Hypoglycemia is associated with increased worry and lower quality of life among patients with type 2 diabetes treated with oral antihyperglycemic agents in the Asia-Pacific region

The impact of structured blood glucose testing on attitudes toward self-management among poorly controlled, insulin-naïve patients with type 2 diabetes

Rural diabetes prevalence quintuples over twenty-five years in low- and middle-income countries: A systematic review and meta-analysis

Health beliefs among individuals at increased familial risk for type 2 diabetes: Implications for prevention

Combination therapy with liraglutide and sulfonylurea for a type 2 diabetic patient with high titer of anti-insulin antibodies produced by insulin therapy

The effect of hyperglycemia and hypoglycemia on glucose transport and expression of glucose transporters in human lymphocytes B and T: Anin vitrostudy

Predictors of suboptimal glycaemic control in type 2 diabetes patients: The role of medication adherence and body mass index in the relationship between glycaemia and age

Use of haemoglobin A1c to detect impaired fasting glucose or Type 2 diabetes in a United Kingdom community based population

Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3–6 years

Experimental and Clinical Endocrinology & Diabetes

Socioeconomic Correlates of Inpatient Spending for Patients with Type 2 Diabetes Mellitus in China: Evidence from Hangzhou

Expression and Significance of Lipin1 and AMPKα in Hepatic Insulin Resistance in Diet-Induced Insulin Resistance Rats

The Control of Hyperglycemia in Alloxan Treated Diabetic Mice through the Stimulation of Hepatic Insulin Synthesis due to the Production of Nitric Oxide

Effective Therapy of Insulinoma by Using Long-Acting Somatostatin Analogue. A Case Report and Literature Review

Benefit of Combined Triiodothyronine (LT3) and Thyroxine (LT4) Treatment in Athyreotic Patients Unresponsive to LT4 Alone

Central FoxO3a and FoxO6 Expression is Down­regulated in Obesity Induced Diabetes but not in Aging

Statins for Primary Prevention of Cardiovascular and Cerebrovascular Events in Diabetic Patients without Established Cardiovascular Diseases: A Meta-Analysis

Diabetes Mellitus and Incidence and Mortality of Gastric Cancer: A Meta-Analysis

Role of the CAG Repeat Polymorphism of the Androgen Receptor Gene in Polycystic Ovary Syndrome (PCOS)

Lipid Infiltration in the Parotid Glands: A Clinical Manifestation of Metabolic Syndrome

The Diabetes Educator (Current Issue)

2011--Another Successful Year for The Diabetes Educator

Disparities in Diabetes Self-management Education for Uninsured and Underinsured Adults

A Year of Achievement Ushers in a New Era for Diabetes Care

Physicians' Perceptions of the Type 2 Diabetes Multi-disciplinary Treatment Team: A Qualitative Study

AADE News

Book Review: The Low GI Handbook: The New Glucose RevolutionTM Guide to the Long-term Health Benefits of Low GI Eating

Looking Ahead

Exploring the Cost and Clinical Outcomes of Integrating the Registered Nurse-Certified Diabetes Educator Into the Patient-Centered Medical Home

The Educator's Guide to Diabetes Resources, 2011

Pharmacist-Led Shared Medical Appointments for Multiple Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

Notes

Important Disclaimer

As a subscriber or visitor of this web-based Social Media Experience about Diabetes, its important that you understand that the blog posts and comments to such blog posts (whether posted by us, bloggers, or our users) do not constitute medical advice or recommendation of any kind.  You should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your…

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Created by Peter Hofland, PhD Dec 6, 2009 at 4:14pm. Last updated by Peter Hofland, PhD Dec 6, 2009.

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Created by Peter Hofland, PhD Sep 13, 2009 at 1:04pm. Last updated by Peter Hofland, PhD Oct 10, 2009.

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About Diabetes Mellitus

Diabetes Mellitus (DM) is a common metabolic disorder associated with abnormally high blood sugar levels. Diabetes is classified as either type 1 (T1DM), which is characterized by severely diminished insulin production, or type 2 (T2DM), which is characterized by moderately diminished insulin production in conjunction with insulin resistance (insensitivity of the tissues of the body to insulin). Insulin is a hormone that regulates blood glucose levels. Diabetes can seriously impair overall quality of life and may lead to multiple complications including heart disease, stroke, and kidney failure. According to the International Diabetes Federation, more than 245 million people have diabetes, with type 2 diabetes being the most prevalent.

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